| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 18] | - | Puebla FC [Sub 18] | 0:0 | ||||
| 2. Jornada | 30.07.2021 | Puebla FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:3 |  |
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| 3. Jornada | 07.08.2021 | CF América [Sub 18] | - | Puebla FC [Sub 18] | 1:0 | ||||
| 4. Jornada | 13.08.2021 | Puebla FC [Sub 18] | - | UANL Tigres [Sub 18] | 1:2 | ||||
| 5. Jornada | 17.08.2021 | Club Tijuana [Sub 18] | - | Puebla FC [Sub 18] | 5:2 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 18] | - | Puebla FC [Sub 18] | 3:3 | |
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| 7. Jornada | 27.08.2021 | Puebla FC [Sub 18] | - | Gallos Blancos [Sub 18] | 2:3 |
México