| 1. Jornada | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 2. Jornada | 15.01.2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 | ||||
| 4. Jornada | 29.01.2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 5. Jornada | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 |  |
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| 6. Jornada | 12.02.2022 | Club Necaxa [] | - | CF Pachuca [] | 2:1 | ||||
| 7. Jornada | 19.02.2022 | CF Pachuca [] | - | Gallos Blancos [] | 3:0 | ||||
| 9. Jornada | 05.03.2022 | Deportivo Toluca [] | - | CF Pachuca [] | 2:4 | ||||
| 12. Jornada | 26.03.2022 | CF Pachuca [] | - | Pumas UNAM [] | 2:2 | ||||
| 14. Jornada | 09.04.2022 | CF Pachuca [] | - | Club Necaxa [] | 0:1 | ||||
| 16. Jornada | 24.04.2022 | CF América [] | - | CF Pachuca [] | 4:3 | ||||
| 18. Jornada | 07.05.2022 | Gallos Blancos [] | - | CF Pachuca [] | 0:0 | |
México