| 1. Jornada | 28.09.2020 | Real España | - | Olimpia | 1:1 | ||||
| 2. Jornada | 07.10.2020 | Platense | - | Real España | 1:0 | ||||
| 4. Jornada | 14.10.2020 | Marathón | - | Real España | 3:0 | ||||
| 7. Jornada | 26.10.2020 | Real España | - | Platense | 3:2 | ||||
| 8. Jornada | 29.10.2020 | Honduras Progreso | - | Real España | 0:3 | ||||
| 9. Jornada | 02.11.2020 | Real España | - | Marathón | 0:1 |  |
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| 13. Jornada | 15.11.2020 | Lobos UPNFM | - | Real España | 1:1 | |
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| 11. Jornada | 26.11.2020 | Real España | - | Real de Minas | 1:1 | ||||
| 6. Jornada | 07.12.2020 | Olimpia | - | Real España | 1:0 | |
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| 14. Jornada | 12.12.2020 | Real Sociedad | - | Real España | 1:2 |
Uruguay