| 1. Jornada | 15.08.2015 | River Plate | - | Fénix | 1:2 |  |
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| 2. Jornada | 23.08.2015 | Nacional | - | River Plate | 2:1 | |
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| 3. Jornada | 29.08.2015 | River Plate | - | Sud América | 2:0 | |
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| 4. Jornada | 05.09.2015 | Montevideo Wanderers | - | River Plate | 5:1 | ||||
| 5. Jornada | 13.09.2015 | River Plate | - | Racing | 3:1 | |
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| 6. Jornada | 20.09.2015 | Plaza Colonia | - | River Plate | 3:2 | ||||
| 7. Jornada | 27.09.2015 | River Plate | - | Peñarol | 4:0 | |
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| 8. Jornada | 04.10.2015 | Juventud de Las Piedras | - | River Plate | 2:3 |  |
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| 9. Jornada | 18.10.2015 | River Plate | - | Danubio | 2:1 | |
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| 10. Jornada | 25.10.2015 | CA Cerro | - | River Plate | 1:1 | |
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| 11. Jornada | 01.11.2015 | River Plate | - | Rentistas | 2:3 | |
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| 12. Jornada | 07.11.2015 | El Tanque Sisley | - | River Plate | 2:1 | |
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| 13. Jornada | 21.11.2015 | River Plate | - | Liverpool | 2:2 | ||||
| 14. Jornada | 28.11.2015 | Defensor Sporting | - | River Plate | 1:2 | |
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| 15. Jornada | 05.12.2015 | River Plate | - | Villa Teresa | 4:0 |
Uruguay
