| 5. Jornada | 30.08.2021 | Seattle Sounders | - | Portland Timbers | 0:2 | ||||
| 6. Jornada | 04.09.2021 | Houston Dynamo | - | Portland Timbers | 0:2 | ||||
| 6. Jornada | 11.09.2021 | Vancouver Whitecaps | - | Portland Timbers | 0:1 |  |
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| 6. Jornada | 20.09.2021 | Portland Timbers | - | Los Angeles FC | 2:1 | ||||
| 6. Jornada | 26.09.2021 | Portland Timbers | - | Real Salt Lake | 6:1 | ||||
| 6. Jornada | 30.09.2021 | Los Angeles FC | - | Portland Timbers | 1:2 | ||||
| 7. Jornada | 03.10.2021 | Portland Timbers | - | Inter Miami CF | 1:0 | ||||
| 7. Jornada | 17.10.2021 | Los Angeles Galaxy | - | Portland Timbers | 2:1 | ||||
| 7. Jornada | 21.10.2021 | Portland Timbers | - | Vancouver Whitecaps | 2:3 | ||||
| 7. Jornada | 24.10.2021 | Colorado Rapids | - | Portland Timbers | 2:0 | ||||
| 7. Jornada | 28.10.2021 | Portland Timbers | - | San Jose Earthquakes | 2:0 | ||||
| 8. Jornada | 04.11.2021 | Real Salt Lake | - | Portland Timbers | 1:3 | ||||
| 8. Jornada | 08.11.2021 | Portland Timbers | - | Austin FC | 3:0 |
Colombia