| 1. Jornada | 24.07.2021 | FK Khimki | - | Zenit | 1:3 |  |
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| 2. Jornada | 01.08.2021 | FK Rostov | - | Zenit | 2:4 | |
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| 3. Jornada | 07.08.2021 | Zenit | - | FK Krasnodar | 3:2 | |
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| 4. Jornada | 15.08.2021 | Lokomotiv Moskva | - | Zenit | 1:1 | ||||
| 5. Jornada | 21.08.2021 | FK Ufa | - | Zenit | 1:1 | ||||
| 6. Jornada | 26.08.2021 | Zenit | - | CSKA Moscú | 1:0 | |
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| 7. Jornada | 11.09.2021 | Zenit | - | Akhmat Grozny | 3:1 | ||||
| 9. Jornada | 25.09.2021 | Zenit | - | Krylia Sovetov | 2:1 | ||||
| 10. Jornada | 03.10.2021 | Zenit | - | FK Sochi | 1:2 |  |
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| 12. Jornada | 24.10.2021 | Zenit | - | Spartak Moskva | 7:1 | |
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| 13. Jornada | 29.10.2021 | Zenit | - | Dinamo Moskva | 4:1 | ||||
| 14. Jornada | 07.11.2021 | FK Ural | - | Zenit | 0:0 | ||||
| 15. Jornada | 19.11.2021 | Zenit | - | FK Nizhny Novgorod | 5:1 |  |
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| 16. Jornada | 28.11.2021 | CSKA Moscú | - | Zenit | 0:2 | |
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| 17. Jornada | 03.12.2021 | Zenit | - | FK Rostov | 2:2 |
Irán