| 4. Jornada | 25.02.2022 | CD Guabirá | - | Nacional Potosí | 1:3 | ||||
| 11. Jornada | 24.04.2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 | ||||
| 14. Jornada | 12.05.2022 | Nacional Potosí | - | The Strongest | 1:1 | ||||
| 15. Jornada | 15.05.2022 | Club Aurora | - | Nacional Potosí | 2:3 |  |
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| 16. Jornada | 21.05.2022 | Nacional Potosí | - | Oriente Petrolero | 4:2 |
Bolivia