| 6. Jornada | 02.08.2010 | Los Angeles Galaxy | - | Chicago Fire | 2:3 |  |
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| 6. Jornada | 09.08.2010 | Chicago Fire | - | New York RB | 0:0 | ||||
| 6. Jornada | 19.08.2010 | Chicago Fire | - | New England Revolution | 2:1 | ||||
| 6. Jornada | 22.08.2010 | Houston Dynamo | - | Chicago Fire | 4:3 | ||||
| 6. Jornada | 29.08.2010 | Seattle Sounders | - | Chicago Fire | 2:1 | ||||
| 7. Jornada | 04.09.2010 | Chicago Fire | - | Los Angeles Galaxy | 1:1 | ||||
| 7. Jornada | 09.09.2010 | Chicago Fire | - | Toronto FC | 0:0 | ||||
| 7. Jornada | 12.09.2010 | Philadelphia Union | - | Chicago Fire | 1:0 | ||||
| 7. Jornada | 18.09.2010 | Real Salt Lake | - | Chicago Fire | 1:0 | ||||
| 7. Jornada | 26.09.2010 | Chicago Fire | - | Seattle Sounders | 0:1 | ||||
| 7. Jornada | 30.09.2010 | San Jose Earthquakes | - | Chicago Fire | 0:3 | ||||
| 8. Jornada | 03.10.2010 | FC Dallas | - | Chicago Fire | 3:0 | ||||
| 8. Jornada | 24.10.2010 | CD Chivas | - | Chicago Fire | 1:4 |
Estados Unidos
Jamaica 