| 3. Jornada | 28.02.2022 | Shamrock Rovers | - | Drogheda United | 3:1 | ||||
| 4. Jornada | 04.03.2022 | Drogheda United | - | UC Dublin | 4:2 | ||||
| 5. Jornada | 11.03.2022 | Drogheda United | - | Sligo Rovers | 0:3 | ||||
| 6. Jornada | 14.03.2022 | Derry City | - | Drogheda United | 2:0 | ||||
| 7. Jornada | 18.03.2022 | Drogheda United | - | Dundalk FC | 1:0 | ||||
| 8. Jornada | 01.04.2022 | St Patrick's Athletic | - | Drogheda United | 1:1 | ||||
| 9. Jornada | 08.04.2022 | Drogheda United | - | Bohemian FC | 1:1 |  |
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| 10. Jornada | 15.04.2022 | UC Dublin | - | Drogheda United | 0:2 | ||||
| 11. Jornada | 18.04.2022 | Drogheda United | - | Derry City | 1:1 | ||||
| 12. Jornada | 23.04.2022 | Sligo Rovers | - | Drogheda United | 3:2 | ||||
| 13. Jornada | 29.04.2022 | Dundalk FC | - | Drogheda United | 4:1 | ||||
| 14. Jornada | 06.05.2022 | Drogheda United | - | St Patrick's Athletic | 0:4 | ||||
| 15. Jornada | 13.05.2022 | Shelbourne FC | - | Drogheda United | 1:0 | ||||
| 16. Jornada | 20.05.2022 | Drogheda United | - | Finn Harps | 3:1 |  |
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| 18. Jornada | 27.05.2022 | Bohemian FC | - | Drogheda United | 1:1 | |
Irlanda