| 4. Jornada | 09.08.2021 | Alianza Petrolera | - | Deportivo Pasto | 2:0 |  |
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| 5. Jornada | 14.08.2021 | Envigado FC | - | Alianza Petrolera | 2:1 | |
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| 16. Jornada | 27.10.2021 | Alianza Petrolera | - | Independiente Medellín | 3:0 | |
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| 17. Jornada | 01.11.2021 | América de Cali | - | Alianza Petrolera | 1:1 | ||||
| 18. Jornada | 06.11.2021 | Alianza Petrolera | - | Atlético Huila | 1:0 | |
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| 19. Jornada | 15.11.2021 | Millonarios | - | Alianza Petrolera | 1:1 | |
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| 20. Jornada | 21.11.2021 | Alianza Petrolera | - | Atlético Junior | 1:1 |
Colombia