| 1. Jornada | 23.01.2022 | Tigres FC | - | Real Cartagena | 1:2 |  |
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| 2. Jornada | 01.02.2022 | Real Cartagena | - | Fortaleza FC | 1:1 | ||||
| 3. Jornada | 06.02.2022 | Barranquilla FC | - | Real Cartagena | 0:2 | |
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| 4. Jornada | 15.02.2022 | Real Cartagena | - | Atlético Huila | 1:1 | ||||
| 7. Jornada | 06.03.2022 | Real Cartagena | - | Atlético FC | 0:0 | ||||
| 8. Jornada | 10.03.2022 | Leones FC | - | Real Cartagena | 1:0 | ||||
| 9. Jornada | 19.03.2022 | Real Cartagena | - | Bogotá FC | 1:1 | ||||
| 10. Jornada | 28.03.2022 | Orsomarso SC | - | Real Cartagena | 1:2 |  |
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| 11. Jornada | 02.04.2022 | Real Cartagena | - | Llaneros FC | 2:0 | ||||
| 12. Jornada | 13.04.2022 | Deportes Quindío | - | Real Cartagena | 5:0 | ||||
| 13. Jornada | 20.04.2022 | Real Cartagena | - | Boyacá Chicó | 3:1 | |
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| 14. Jornada | 25.04.2022 | Boca Juniors de Cali | - | Real Cartagena | 1:2 | ||||
| 15. Jornada | 04.05.2022 | Real Cartagena | - | Valledupar FC | 1:2 |
Colombia