| 6. Jornada | 28.08.2010 | Club San José | - | Real Potosí | 2:3 | ||||
| 7. Jornada | 05.09.2010 | Oriente Petrolero | - | Club San José | 2:1 | ||||
| 8. Jornada | 11.09.2010 | Club San José | - | Club Aurora | 3:3 | ||||
| 10. Jornada | 18.09.2010 | Club San José | - | Real Mamoré | 1:0 |  |
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| 11. Jornada | 25.09.2010 | La Paz FC | - | Club San José | 4:3 | ||||
| 12. Jornada | 03.10.2010 | Club San José | - | Universitario de Sucre | 2:1 | |
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| 14. Jornada | 10.10.2010 | Club San José | - | Jorge Wilstermann | 2:0 | ||||
| 16. Jornada | 24.10.2010 | Club San José | - | CD Guabirá | 5:1 | ||||
| 18. Jornada | 31.10.2010 | Club San José | - | Oriente Petrolero | 0:3 | ||||
| 19. Jornada | 07.11.2010 | Club Aurora | - | Club San José | 4:1 | ||||
| 20. Jornada | 14.11.2010 | Club San José | - | Bolívar | 0:1 | ||||
| 21. Jornada | 21.11.2010 | Real Mamoré | - | Club San José | 3:0 | ||||
| 22. Jornada | 28.11.2010 | Club San José | - | La Paz FC | 1:0 | |
Bolivia