| 2. Jornada | 16.01.2022 | CF Pachuca [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 |  |
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| 3. Jornada | 22.01.2022 | Deportivo Guadalajara [Sub 20] | - | Gallos Blancos [Sub 20] | 0:0 | ||||
| 16. Jornada | 23.04.2022 | Deportivo Guadalajara [Sub 20] | - | Pumas UNAM [Sub 20] | 3:1 | ||||
| 17. Jornada | 29.04.2022 | Club Necaxa [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 0:3 |
México