| 1. Jornada | 06.01.2013 | Puebla FC | - | Club Tijuana | 1:2 | ||||
| 2. Jornada | 13.01.2013 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 3. Jornada | 20.01.2013 | Puebla FC | - | Santos Laguna | 2:1 | ||||
| 4. Jornada | 27.01.2013 | Cruz Azul | - | Puebla FC | 4:0 | ||||
| 5. Jornada | 03.02.2013 | Puebla FC | - | Monarcas Morelia | 3:1 | ||||
| 6. Jornada | 10.02.2013 | Club San Luis | - | Puebla FC | 1:3 | ||||
| 7. Jornada | 17.02.2013 | Puebla FC | - | Deportivo Guadalajara | 1:1 | ||||
| 8. Jornada | 24.02.2013 | CF Monterrey | - | Puebla FC | 3:0 | ||||
| 9. Jornada | 03.03.2013 | Club León | - | Puebla FC | 0:1 | ||||
| 10. Jornada | 10.03.2013 | Puebla FC | - | Pumas UNAM | 0:1 |  |
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| 11. Jornada | 17.03.2013 | CF Pachuca | - | Puebla FC | 2:1 | ||||
| 12. Jornada | 31.03.2013 | Puebla FC | - | UANL Tigres | 1:2 | ||||
| 13. Jornada | 07.04.2013 | CF América | - | Puebla FC | 1:1 | ||||
| 14. Jornada | 14.04.2013 | Puebla FC | - | Jaguares Chiapas | 1:2 | ||||
| 15. Jornada | 22.04.2013 | Atlante | - | Puebla FC | 2:0 | ||||
| 16. Jornada | 28.04.2013 | Puebla FC | - | Atlas Guadalajara | 1:1 | ||||
| 17. Jornada | 05.05.2013 | Gallos Blancos (old) | - | Puebla FC | 2:3 |
Ecuador