| 2. Jornada | 02.05.2021 | San Antonio FC | - | Colorado Springs Switchbacks | 3:0 | ||||
| 2. Jornada | 17.05.2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 | ||||
| 3. Jornada | 06.06.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 3. Jornada | 17.06.2021 | New Mexico United | - | San Antonio FC | 2:0 | ||||
| 3. Jornada | 27.06.2021 | Real Monarchs SLC | - | San Antonio FC | 1:1 | ||||
| 4. Jornada | 17.07.2021 | Colorado Springs Switchbacks | - | San Antonio FC | 2:3 |  |
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| 5. Jornada | 29.08.2021 | San Antonio FC | - | El Paso Locomotive | 2:1 | ||||
| 6. Jornada | 05.09.2021 | San Antonio FC | - | Pittsburgh Riverhounds | 1:1 | ||||
| 6. Jornada | 26.09.2021 | San Antonio FC | - | New Mexico United | 0:1 | ||||
| 7. Jornada | 04.10.2021 | OKC Energy FC | - | San Antonio FC | 0:1 | |
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| 7. Jornada | 07.10.2021 | El Paso Locomotive | - | San Antonio FC | 3:3 |
Estados Unidos