| 9. Jornada | 15.02.2022 | Smouha Sporting Club | - | Zamalek | 2:0 | ||||
| 10. Jornada | 02.03.2022 | Zamalek | - | Future FC | 3:2 | ||||
| 13. Jornada | 09.04.2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Jornada | 12.04.2022 | Zamalek | - | Pharco FC | 0:0 | ||||
| 15. Jornada | 19.04.2022 | Ittihad El Iskandary | - | Zamalek | 0:2 | ||||
| 16. Jornada | 28.04.2022 | Zamalek | - | Al Masry Club | 2:1 | ||||
| 17. Jornada | 01.05.2022 | El Sharkia Lel Dokhan | - | Zamalek | 1:2 | ||||
| 20. Jornada | 19.06.2022 | Al Ahly SC | - | Zamalek | 2:2 |  |
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| 22. Jornada | 22.06.2022 | National Bank SC | - | Zamalek | 1:2 | ||||
| 23. Jornada | 28.06.2022 | Zamalek | - | Ceramica Cleopatra | 3:2 | ||||
| 24. Jornada | 12.07.2022 | Zamalek | - | Al Mokawloon | 1:0 | ||||
| 25. Jornada | 16.07.2022 | Ghazl Al Mehalla | - | Zamalek | 0:2 | ||||
| 26. Jornada | 24.07.2022 | Zamalek | - | Smouha Sporting Club | 2:0 | ||||
| 27. Jornada | 28.07.2022 | Future FC | - | Zamalek | 0:1 | ||||
| 28. Jornada | 01.08.2022 | Zamalek | - | Pyramids FC | 3:0 | |
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| 29. Jornada | 05.08.2022 | El Gouna | - | Zamalek | 1:4 | ||||
| 30. Jornada | 09.08.2022 | Zamalek | - | Misr lel-Maqasah SC | 5:0 | ||||
| 31. Jornada | 19.08.2022 | Pharco FC | - | Zamalek | 0:1 | ||||
| 32. Jornada | 23.08.2022 | Zamalek | - | Ittihad El Iskandary | 1:1 |
Egipto