| 19. Jornada | 03.08.2018 | Bhayangkara Surabaya United F.C | - | PSMS Medan (ISL) | 3:1 | ||||
| 20. Jornada | 12.08.2018 | Persija Jakarta | - | PSMS Medan (ISL) | 0:0 | ||||
| 21. Jornada | 12.09.2018 | PSMS Medan (ISL) | - | PSIS Semarang | 2:3 |  |
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| 22. Jornada | 16.09.2018 | Perseru Serui | - | PSMS Medan (ISL) | 1:1 | ||||
| 23. Jornada | 21.09.2018 | PSMS Medan (ISL) | - | Persela Lamongan | 3:2 | |
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| 24. Jornada | 07.10.2018 | PS Barito Putera | - | PSMS Medan (ISL) | 3:3 | |
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| 26. Jornada | 18.10.2018 | Sriwijaya FC | - | PSMS Medan (ISL) | 0:3 | |
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| 27. Jornada | 23.10.2018 | PSMS Medan (ISL) | - | Mitra Kukar | 1:3 | |
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| 28. Jornada | 28.10.2018 | Arema Cronus FC | - | PSMS Medan (ISL) | 5:0 | ||||
| 29. Jornada | 03.11.2018 | PSMS Medan (ISL) | - | Pusamania Borneo F.C. | 3:2 | |
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| 30. Jornada | 09.11.2018 | Persib Bandung | - | PSMS Medan (ISL) | 0:1 | ||||
| 31. Jornada | 17.11.2018 | PSMS Medan (ISL) | - | Madura United | 3:3 | ||||
| 32. Jornada | 24.11.2018 | Persipura Jayapura | - | PSMS Medan (ISL) | 3:1 | |
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| 33. Jornada | 01.12.2018 | PSMS Medan (ISL) | - | Persebaya Surabaya | 4:0 | |
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| 25. Jornada | 05.12.2018 | PSMS Medan (ISL) | - | PS-TIRA | 2:4 |  |
Japón