| 2. Jornada | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 |  |
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| 3. Jornada | 18.02.2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | |
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| 4. Jornada | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 5. Jornada | 06.03.2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
| 9. Jornada | 16.04.2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 |
Paraguay