| 6. Jornada | 16.08.2021 | Talleres de Córdoba | - | San Lorenzo | 2:0 |  |
|||
| 9. Jornada | 30.08.2021 | San Lorenzo | - | Patronato de Paraná | 3:0 | ||||
| 10. Jornada | 04.09.2021 | Platense | - | San Lorenzo | 1:1 |  |
|||
| 11. Jornada | 13.09.2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
| 12. Jornada | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Jornada | 26.09.2021 | San Lorenzo | - | Defensa y Justicia | 2:1 |  |
|||
| 14. Jornada | 02.10.2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 15. Jornada | 11.10.2021 | San Lorenzo | - | Colón de Santa Fe | 1:2 | ||||
| 16. Jornada | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | |
|||
| 17. Jornada | 20.10.2021 | San Lorenzo | - | CA Lanús | 1:3 | ||||
| 22. Jornada | 23.11.2021 | Aldosivi | - | San Lorenzo | 2:0 | ||||
| 25. Jornada | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 | |
Argentina