| 2. Jornada | 12.09.2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 |  |
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| 3. Jornada | 20.09.2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 4. Jornada | 25.09.2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 | ||||
| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 6. Jornada | 17.10.2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | |
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| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 9. Jornada | 07.11.2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 10. Jornada | 20.11.2021 | Olympiacos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Jornada | 29.11.2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | |
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| 12. Jornada | 04.12.2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | |
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| 1. Jornada | 22.12.2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | ||||
| 18. Jornada | 24.01.2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | |
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| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | |
Grecia