| Zona B | 21.02.2021 | Cobán Imperial | - | CSD Municipal | 1:0 | ||||
| Zona B | 27.02.2021 | CSD Municipal | - | Deportivo Guastatoya | 0:1 | ||||
| Zona B | 03.03.2021 | CSD Municipal | - | Sanarate | 3:1 | ||||
| Zona B | 07.03.2021 | Achuapa | - | CSD Municipal | 1:2 | ||||
| Zona B | 10.03.2021 | CSD Municipal | - | Sacachispas | 1:2 |  |
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| Zona B | 13.03.2021 | CSD Municipal | - | Cobán Imperial | 2:0 | ||||
| Zona B | 01.04.2021 | Deportivo Guastatoya | - | CSD Municipal | 0:0 | |
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| Zona B | 04.04.2021 | Sanarate | - | CSD Municipal | 2:1 | ||||
| Zona B | 07.04.2021 | CSD Municipal | - | Achuapa | 3:0 | |
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| Zona B | 11.04.2021 | Sacachispas | - | CSD Municipal | 0:3 | |
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| Interzona | 18.04.2021 | Antigua GFC | - | CSD Municipal | 1:1 | ||||
| Interzona | 21.04.2021 | CSD Municipal | - | Comunicaciones | 0:1 | ||||
| Interzona | 24.04.2021 | Iztapa | - | CSD Municipal | 0:0 | ||||
| Interzona | 28.04.2021 | CSD Municipal | - | Santa Lucía | 2:1 | ||||
| Interzona | 02.05.2021 | Xelaju MC | - | CSD Municipal | 0:3 | ||||
| Cuartos de final | 06.05.2021 | Iztapa | - | CSD Municipal | 3:1 | |
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| Cuartos de final | 09.05.2021 | CSD Municipal | - | Iztapa | 0:0 | |
Uruguay