| 1. Jornada | 31.07.2021 | CSD Municipal | - | Deportivo Guastatoya | 1:0 |  |
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| 2. Jornada | 07.08.2021 | Santa Lucía | - | CSD Municipal | 1:1 |  |
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| 4. Jornada | 14.08.2021 | CSD Municipal | - | Iztapa | 2:2 | ||||
| 13. Jornada | 09.10.2021 | CSD Municipal | - | Santa Lucía | 1:1 | ||||
| 11. Jornada | 14.10.2021 | Antigua GFC | - | CSD Municipal | 1:1 | ||||
| 14. Jornada | 17.10.2021 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 15. Jornada | 23.10.2021 | Iztapa | - | CSD Municipal | 1:0 |  |
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| 16. Jornada | 27.10.2021 | CSD Municipal | - | Xelaju MC | 3:0 | ||||
| 17. Jornada | 01.11.2021 | Sololá FC | - | CSD Municipal | 1:4 | ||||
| 18. Jornada | 06.11.2021 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 19. Jornada | 14.11.2021 | Achuapa | - | CSD Municipal | 0:1 | ||||
| 20. Jornada | 20.11.2021 | CSD Municipal | - | Comunicaciones | 0:0 | |
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| 21. Jornada | 28.11.2021 | Cobán Imperial | - | CSD Municipal | 0:1 | ||||
| 22. Jornada | 05.12.2021 | CSD Municipal | - | Antigua GFC | 1:0 |
Uruguay