| 1. Jornada | 16.01.2022 | Santa Lucía | - | CSD Municipal | 0:2 | ||||
| 2. Jornada | 22.01.2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 |  |
|||
| 3. Jornada | 30.01.2022 | Sololá FC | - | CSD Municipal | 0:3 | ||||
| 4. Jornada | 02.02.2022 | CSD Municipal | - | Comunicaciones | 2:0 |  |
|||
| 7. Jornada | 13.02.2022 | Nueva Concepción | - | CSD Municipal | 1:0 | |
|||
| 10. Jornada | 03.03.2022 | Antigua GFC | - | CSD Municipal | 1:3 |  |
|||
| 11. Jornada | 05.03.2022 | CSD Municipal | - | Achuapa | 0:1 | |
|||
| 12. Jornada | 12.03.2022 | CSD Municipal | - | Santa Lucía | 2:1 | ||||
| 13. Jornada | 20.03.2022 | Deportivo Guastatoya | - | CSD Municipal | 1:2 | ||||
| 15. Jornada | 04.04.2022 | Comunicaciones | - | CSD Municipal | 2:0 | |
|||
| 16. Jornada | 09.04.2022 | CSD Municipal | - | Deportivo Malacateco | 2:0 | ||||
| 19. Jornada | 13.04.2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 17. Jornada | 17.04.2022 | Xelaju MC | - | CSD Municipal | 0:1 | ||||
| 18. Jornada | 20.04.2022 | CSD Municipal | - | Nueva Concepción | 2:0 | |
|||
| 20. Jornada | 30.04.2022 | CSD Municipal | - | Iztapa | 3:1 | ||||
| 21. Jornada | 04.05.2022 | CSD Municipal | - | Antigua GFC | 0:1 | |
|||
| 22. Jornada | 08.05.2022 | Achuapa | - | CSD Municipal | 0:0 |
Uruguay