| 4. Jornada | 22.07.2021 | Colorado Rapids | - | FC Dallas | 2:0 | ||||
| 4. Jornada | 25.07.2021 | Real Salt Lake | - | Colorado Rapids | 3:0 | ||||
| 5. Jornada | 01.08.2021 | Austin FC | - | Colorado Rapids | 0:1 | ||||
| 5. Jornada | 08.08.2021 | Colorado Rapids | - | Sporting Kansas City | 0:0 |  |
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| 5. Jornada | 18.08.2021 | Los Angeles Galaxy | - | Colorado Rapids | 1:2 | ||||
| 6. Jornada | 05.09.2021 | San Jose Earthquakes | - | Colorado Rapids | 0:1 | ||||
| 6. Jornada | 30.09.2021 | Colorado Rapids | - | Austin FC | 3:0 | ||||
| 7. Jornada | 24.10.2021 | Colorado Rapids | - | Portland Timbers | 2:0 | ||||
| 7. Jornada | 28.10.2021 | New England Revolution | - | Colorado Rapids | 1:0 | ||||
| 7. Jornada | 31.10.2021 | Houston Dynamo | - | Colorado Rapids | 0:1 | ||||
| 8. Jornada | 08.11.2021 | Colorado Rapids | - | Los Angeles FC | 5:2 |
Estados Unidos