| 1. Jornada | 07.11.2021 | Pierikos Katerini | - | Xanthi FC | 1:1 | ||||
| 3. Jornada | 21.11.2021 | Xanthi FC | - | Thesprotos | 1:0 |  |
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| 4. Jornada | 24.11.2021 | AO Kavala | - | Xanthi FC | 0:6 | ||||
| 5. Jornada | 28.11.2021 | Xanthi FC | - | Almopos Arideas | 2:0 | ||||
| 6. Jornada | 05.12.2021 | Niki Volou FC | - | Xanthi FC | 0:1 | ||||
| 7. Jornada | 11.12.2021 | Xanthi FC | - | Olympiacos Volou | 2:0 | ||||
| 8. Jornada | 15.12.2021 | PAOK Saloniki II | - | Xanthi FC | 0:1 |  |
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| 9. Jornada | 19.12.2021 | Xanthi FC | - | AO Trikala | 5:0 | ||||
| 15. Jornada | 22.01.2022 | Xanthi FC | - | Veria FC | 0:3 | ||||
| 11. Jornada | 26.01.2022 | Xanthi FC | - | Apollon Lárissa | 0:0 | ||||
| 17. Jornada | 06.02.2022 | Xanthi FC | - | Anagennisi Karditsa | 5:2 | ||||
| 13. Jornada | 09.02.2022 | Xanthi FC | - | Panserraikos | 0:0 | ||||
| 18. Jornada | 13.02.2022 | Xanthi FC | - | Pierikos Katerini | 3:0 | ||||
| 20. Jornada | 20.02.2022 | Thesprotos | - | Xanthi FC | 0:0 | ||||
| 22. Jornada | 06.03.2022 | Almopos Arideas | - | Xanthi FC | 2:2 | ||||
| 23. Jornada | 09.03.2022 | Xanthi FC | - | Niki Volou FC | 0:0 |
Francia
Haití