| 7. Jornada | 03.10.2021 | Philadelphia Union | - | Columbus Crew | 3:0 | ||||
| 7. Jornada | 17.10.2021 | Columbus Crew | - | Inter Miami CF | 4:0 | ||||
| 7. Jornada | 21.10.2021 | Nashville SC | - | Columbus Crew | 1:1 | ||||
| 7. Jornada | 24.10.2021 | Columbus Crew | - | New York RB | 1:2 | ||||
| 7. Jornada | 28.10.2021 | Columbus Crew | - | Orlando City | 3:2 | ||||
| 7. Jornada | 31.10.2021 | D.C. United | - | Columbus Crew | 1:3 | ||||
| 8. Jornada | 07.11.2021 | Columbus Crew | - | Chicago Fire | 2:0 |
Francia