| 1. Jornada | 29.07.2000 | Guingamp | - | Saint-Étienne | 2:2 | ||||
| 2. Jornada | 05.08.2000 | RC Lens | - | Guingamp | 3:2 | ||||
| 3. Jornada | 12.08.2000 | Guingamp | - | Nantes | 0:1 | ||||
| 4. Jornada | 20.08.2000 | Mónaco | - | Guingamp | 1:0 | ||||
| 5. Jornada | 26.08.2000 | Marsella | - | Guingamp | 3:1 | ||||
| 9. Jornada | 23.09.2000 | Lyon | - | Guingamp | 0:1 | ||||
| 10. Jornada | 30.09.2000 | Guingamp | - | París Saint-Germain | 1:1 | ||||
| 11. Jornada | 14.10.2000 | Lille | - | Guingamp | 1:1 | ||||
| 13. Jornada | 29.10.2000 | Rennes | - | Guingamp | 1:2 | ||||
| 14. Jornada | 04.11.2000 | Guingamp | - | CS Sedan | 0:3 | ||||
| 15. Jornada | 11.11.2000 | FC Metz | - | Guingamp | 1:1 | ||||
| 19. Jornada | 02.12.2000 | Nantes | - | Guingamp | 2:1 | ||||
| 20. Jornada | 09.12.2000 | Guingamp | - | Mónaco | 2:2 |  |
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| 23. Jornada | 13.01.2001 | Guingamp | - | Girondins de Burdeos | 1:1 | |
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| 24. Jornada | 27.01.2001 | AJ Auxerre | - | Guingamp | 1:1 | ||||
| 27. Jornada | 17.02.2001 | Guingamp | - | Lille | 0:1 | ||||
| 29. Jornada | 17.03.2001 | Guingamp | - | Rennes | 1:6 | ||||
| 30. Jornada | 07.04.2001 | CS Sedan | - | Guingamp | 2:2 | ||||
| 31. Jornada | 14.04.2001 | Guingamp | - | FC Metz | 1:3 |
Francia