| 1. Jornada | 26.10.2021 | Zamalek | - | ENPPI | 2:0 |  |
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| 2. Jornada | 31.10.2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 3. Jornada | 05.11.2021 | Zamalek | - | Al Ahly SC | 3:5 | |
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| 4. Jornada | 19.11.2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 5. Jornada | 22.11.2021 | Zamalek | - | National Bank SC | 1:1 | ||||
| 6. Jornada | 25.11.2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 7. Jornada | 21.12.2021 | Al Mokawloon | - | Zamalek | 1:2 | |
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| 11. Jornada | 06.04.2022 | Pyramids FC | - | Zamalek | 2:3 | |
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| 13. Jornada | 09.04.2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Jornada | 12.04.2022 | Zamalek | - | Pharco FC | 0:0 | ||||
| 15. Jornada | 19.04.2022 | Ittihad El Iskandary | - | Zamalek | 0:2 | ||||
| 16. Jornada | 28.04.2022 | Zamalek | - | Al Masry Club | 2:1 | |
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| 17. Jornada | 01.05.2022 | El Sharkia Lel Dokhan | - | Zamalek | 1:2 | ||||
| 18. Jornada | 10.05.2022 | Zamalek | - | ENPPI | 0:2 | |
Egipto