| 1. Jornada | 14.08.2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 6. Jornada | 25.09.2021 | RWD Molenbeek | - | Lommel SK | 1:2 | ||||
| 7. Jornada | 03.10.2021 | SK Deinze | - | RWD Molenbeek | 1:2 | ||||
| 8. Jornada | 17.10.2021 | RWD Molenbeek | - | KVC Westerlo | 1:2 |  |
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| 10. Jornada | 31.10.2021 | Lommel SK | - | RWD Molenbeek | 2:3 | ||||
| 12. Jornada | 21.11.2021 | Excelsior Virton | - | RWD Molenbeek | 0:2 | |
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| 13. Jornada | 28.11.2021 | RWD Molenbeek | - | SK Deinze | 2:2 | |
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| 14. Jornada | 04.12.2021 | Waasland-Beveren | - | RWD Molenbeek | 2:3 | ||||
| 16. Jornada | 19.12.2021 | Lierse Kempenzonen | - | RWD Molenbeek | 0:1 | ||||
| 17. Jornada | 21.01.2022 | RWD Molenbeek | - | Lommel SK | 2:0 | ||||
| 15. Jornada | 25.01.2022 | RWD Molenbeek | - | KVC Westerlo | 0:2 | ||||
| 18. Jornada | 30.01.2022 | RWD Molenbeek | - | Royal Excel Mouscron | 2:0 | ||||
| 22. Jornada | 27.02.2022 | RWD Molenbeek | - | Lierse Kempenzonen | 3:1 | |
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| 23. Jornada | 06.03.2022 | Royal Excel Mouscron | - | RWD Molenbeek | 0:1 | ||||
| 25. Jornada | 20.03.2022 | RWD Molenbeek | - | Excelsior Virton | 3:0 | |
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| 26. Jornada | 03.04.2022 | SK Deinze | - | RWD Molenbeek | 3:0 | ||||
| 27. Jornada | 09.04.2022 | RWD Molenbeek | - | Waasland-Beveren | 2:1 | |
Bélgica