| 7. Jornada | 17.09.2021 | Almere City FC | - | Jong Ajax | 2:4 |  |
|||
| 10. Jornada | 10.10.2021 | Almere City FC | - | De Graafschap | 1:2 | ||||
| 11. Jornada | 15.10.2021 | FC Den Bosch | - | Almere City FC | 1:0 | ||||
| 13. Jornada | 01.11.2021 | Helmond Sport | - | Almere City FC | 1:2 | ||||
| 14. Jornada | 07.11.2021 | Almere City FC | - | ADO Den Haag | 1:3 | ||||
| 16. Jornada | 19.11.2021 | Almere City FC | - | MVV | 0:2 | ||||
| 18. Jornada | 03.12.2021 | Almere City FC | - | FC Eindhoven | 2:0 | ||||
| 22. Jornada | 14.01.2022 | Almere City FC | - | Roda JC Kerkrade | 0:4 | ||||
| 23. Jornada | 21.01.2022 | De Graafschap | - | Almere City FC | 1:0 | ||||
| 24. Jornada | 30.01.2022 | Almere City FC | - | Telstar | 0:0 | ||||
| 25. Jornada | 04.02.2022 | FC Dordrecht | - | Almere City FC | 2:2 | |
|||
| 26. Jornada | 11.02.2022 | Almere City FC | - | FC Emmen | 0:0 | ||||
| 27. Jornada | 21.02.2022 | Jong Ajax | - | Almere City FC | 1:3 | |
|||
| 28. Jornada | 25.02.2022 | Almere City FC | - | VVV-Venlo | 0:1 | ||||
| 29. Jornada | 07.03.2022 | FC Utrecht (J) | - | Almere City FC | 1:2 | |
|||
| 38. Jornada | 06.05.2022 | Almere City FC | - | AZ Alkmaar (J) | 0:3 |
Países Bajos