| 1. Jornada | 12.08.2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 2. Jornada | 20.08.2021 | Sliema Wanderers | - | Floriana FC | 0:0 | ||||
| 3. Jornada | 11.09.2021 | Gżira United | - | Sliema Wanderers | 1:1 | ||||
| 4. Jornada | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 6. Jornada | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Jornada | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 |  |
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| 8. Jornada | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
| 13. Jornada | 19.12.2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
| 14. Jornada | 18.01.2022 | Sliema Wanderers | - | Gżira United | 1:3 | ||||
| 15. Jornada | 22.01.2022 | Gudja United | - | Sliema Wanderers | 1:0 | |
Malta