| 1. Jornada | 13.08.2021 | TuS Mechtersheim | - | FC Speyer 09 | 3:0 | ||||
| 2. Jornada | 21.08.2021 | FC Speyer 09 | - | Wormatia Worms | 0:4 |  |
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| 5. Jornada | 06.09.2021 | FC Speyer 09 | - | FV Dudenhofen | 0:6 | ||||
| 6. Jornada | 12.09.2021 | SV 07 Elversberg II | - | FC Speyer 09 | 2:3 | ||||
| 7. Jornada | 18.09.2021 | FC Speyer 09 | - | FSV Jägersburg | 0:5 | ||||
| 12. Jornada | 18.10.2021 | FC Speyer 09 | - | TuS Mechtersheim | 2:3 | ||||
| 15. Jornada | 31.10.2021 | FC Speyer 09 | - | Arminia Ludwigshafen | 3:4 | ||||
| 16. Jornada | 08.11.2021 | FV Dudenhofen | - | FC Speyer 09 | 5:2 | ||||
| 18. Jornada | 20.11.2021 | FSV Jägersburg | - | FC Speyer 09 | 4:2 | ||||
| 19. Jornada | 24.11.2021 | FC Speyer 09 | - | SV Röchling Völklingen | 0:1 | ||||
| 20. Jornada | 27.11.2021 | FV 07 Diefflen | - | FC Speyer 09 | 2:1 |
Alemania