| 1. Jornada | 21.08.2021 | USV Eschen/Mauren | - | FC Uzwil | 4:0 | ||||
| 2. Jornada | 28.08.2021 | FC Uzwil | - | FC Thalwil | 1:2 | ||||
| 6. Jornada | 25.09.2021 | FC Uzwil | - | FC Paradiso | 1:1 | ||||
| 7. Jornada | 02.10.2021 | FC Freienbach | - | FC Uzwil | 2:2 | ||||
| 8. Jornada | 16.10.2021 | FC Uzwil | - | FC St. Gallen II | 0:4 |  |
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| 11. Jornada | 06.11.2021 | FC Uzwil | - | FC Balzers | 3:2 | ||||
| 12. Jornada | 13.11.2021 | FC Tuggen | - | FC Uzwil | 3:1 | ||||
| 13. Jornada | 20.11.2021 | FC Uzwil | - | FC Linth 04 | 4:2 | ||||
| 14. Jornada | 27.11.2021 | FC Uzwil | - | USV Eschen/Mauren | 2:2 |  |
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| 15. Jornada | 05.03.2022 | FC Thalwil | - | FC Uzwil | 0:3 | ||||
| 17. Jornada | 19.03.2022 | FC Baden | - | FC Uzwil | 3:1 | ||||
| 20. Jornada | 09.04.2022 | FC Uzwil | - | FC Freienbach | 0:1 | ||||
| 18. Jornada | 13.04.2022 | FC Uzwil | - | FC Wettswil-Bonstetten | 0:2 | ||||
| 21. Jornada | 23.04.2022 | FC St. Gallen II | - | FC Uzwil | 3:2 |  |
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| 22. Jornada | 30.04.2022 | FC Uzwil | - | FC Winterthur II | 1:0 | ||||
| 23. Jornada | 07.05.2022 | FC Uzwil | - | FC Lugano II | 3:2 | ||||
| 24. Jornada | 14.05.2022 | FC Balzers | - | FC Uzwil | 7:3 | ||||
| 25. Jornada | 21.05.2022 | FC Uzwil | - | FC Tuggen | 1:2 | |
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| 26. Jornada | 28.05.2022 | FC Linth 04 | - | FC Uzwil | 3:1 |
Suiza