| 27. Jornada | 15.01.2022 | Colchester United | - | Barrow AFC | 0:2 |  |
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| 24. Jornada | 18.01.2022 | Sutton United | - | Colchester United | 3:2 | |
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| 28. Jornada | 22.01.2022 | Salford City | - | Colchester United | 0:3 | ||||
| 29. Jornada | 29.01.2022 | Colchester United | - | Swindon Town | 1:1 | ||||
| 26. Jornada | 01.02.2022 | Colchester United | - | Rochdale AFC | 1:1 | ||||
| 34. Jornada | 26.02.2022 | Colchester United | - | Oldham Athletic | 1:1 | ||||
| 23. Jornada | 01.03.2022 | Colchester United | - | Leyton Orient | 2:2 | ||||
| 35. Jornada | 05.03.2022 | Colchester United | - | Port Vale FC | 1:0 |  |
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| 39. Jornada | 26.03.2022 | Colchester United | - | Tranmere Rovers | 1:0 |
Inglaterra