| 4. Jornada | 24.02.2022 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 | ||||
| 5. Jornada | 04.03.2022 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 6. Jornada | 10.03.2022 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 7. Jornada | 18.03.2022 | Rosario Central II | - | Newell's Old Boys II | 2:1 | ||||
| 9. Jornada | 08.04.2022 | Unión de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Jornada | 19.04.2022 | Newell's Old Boys II | - | Banfield II | 1:0 | ||||
| 12. Jornada | 26.04.2022 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 13. Jornada | 30.04.2022 | Newell's Old Boys II | - | San Lorenzo II | 0:3 | ||||
| 14. Jornada | 05.05.2022 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:3 |
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