| 1. Jornada | 17.04.2021 | Houston Dynamo | - | San Jose Earthquakes | 2:1 | ||||
| 1. Jornada | 24.04.2021 | San Jose Earthquakes | - | FC Dallas | 3:1 | ||||
| 2. Jornada | 02.05.2021 | San Jose Earthquakes | - | D.C. United | 4:1 | ||||
| 2. Jornada | 08.05.2021 | Real Salt Lake | - | San Jose Earthquakes | 1:2 | ||||
| 2. Jornada | 13.05.2021 | San Jose Earthquakes | - | Seattle Sounders | 0:1 | ||||
| 2. Jornada | 23.05.2021 | San Jose Earthquakes | - | Sporting Kansas City | 1:3 | ||||
| 2. Jornada | 30.05.2021 | Los Angeles Galaxy | - | San Jose Earthquakes | 1:0 | ||||
| 3. Jornada | 20.06.2021 | Austin FC | - | San Jose Earthquakes | 0:0 | ||||
| 3. Jornada | 23.06.2021 | Orlando City | - | San Jose Earthquakes | 5:0 | ||||
| 6. Jornada | 19.09.2021 | Austin FC | - | San Jose Earthquakes | 3:4 | ||||
| 6. Jornada | 26.09.2021 | San Jose Earthquakes | - | Los Angeles FC | 2:0 | ||||
| 7. Jornada | 21.10.2021 | San Jose Earthquakes | - | Austin FC | 4:0 | ||||
| 7. Jornada | 24.10.2021 | San Jose Earthquakes | - | Vancouver Whitecaps | 1:1 |  |
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| 7. Jornada | 28.10.2021 | Portland Timbers | - | San Jose Earthquakes | 2:0 |
Estados Unidos