| 25. Jornada | 02.02.2021 | Crawley Town | - | Leyton Orient | 0:0 | ||||
| 28. Jornada | 06.02.2021 | Leyton Orient | - | Colchester United | 0:0 | ||||
| 30. Jornada | 20.02.2021 | Leyton Orient | - | Port Vale FC | 1:1 | ||||
| 31. Jornada | 23.02.2021 | Bradford City | - | Leyton Orient | 1:0 | ||||
| 32. Jornada | 27.02.2021 | Leyton Orient | - | Tranmere Rovers | 1:3 | ||||
| 33. Jornada | 02.03.2021 | Grimsby Town | - | Leyton Orient | 0:1 | ||||
| 34. Jornada | 06.03.2021 | Exeter City | - | Leyton Orient | 4:0 | ||||
| 35. Jornada | 09.03.2021 | Leyton Orient | - | Stevenage FC | 0:0 | ||||
| 36. Jornada | 13.03.2021 | Leyton Orient | - | Scunthorpe United | 1:1 | ||||
| 38. Jornada | 27.03.2021 | Leyton Orient | - | Oldham Athletic | 2:1 |  |
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| 41. Jornada | 10.04.2021 | Cheltenham Town | - | Leyton Orient | 1:0 | ||||
| 29. Jornada | 13.04.2021 | Harrogate Town | - | Leyton Orient | 2:2 | ||||
| 42. Jornada | 17.04.2021 | Leyton Orient | - | Barrow AFC | 2:0 | ||||
| 44. Jornada | 24.04.2021 | Southend United | - | Leyton Orient | 2:1 |
Inglaterra