| 2. Jornada | 05.03.2022 | Sporting Kansas City | - | Houston Dynamo | 1:0 | ||||
| 2. Jornada | 20.03.2022 | Houston Dynamo | - | Colorado Rapids | 1:1 |  |
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| 3. Jornada | 03.04.2022 | Inter Miami CF | - | Houston Dynamo | 1:3 | ||||
| 3. Jornada | 10.04.2022 | Houston Dynamo | - | San Jose Earthquakes | 4:3 | ||||
| 3. Jornada | 17.04.2022 | Houston Dynamo | - | Portland Timbers | 0:0 | ||||
| 3. Jornada | 23.04.2022 | FC Dallas | - | Houston Dynamo | 2:1 | ||||
| 3. Jornada | 30.04.2022 | Houston Dynamo | - | Austin FC | 1:2 | ||||
| 4. Jornada | 08.05.2022 | D.C. United | - | Houston Dynamo | 2:0 | ||||
| 4. Jornada | 15.05.2022 | Houston Dynamo | - | Nashville SC | 2:0 | ||||
| 4. Jornada | 19.05.2022 | Houston Dynamo | - | Seattle Sounders | 0:1 | ||||
| 4. Jornada | 23.05.2022 | Los Angeles Galaxy | - | Houston Dynamo | 0:3 | |
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| 4. Jornada | 29.05.2022 | Real Salt Lake | - | Houston Dynamo | 3:0 | ||||
| 5. Jornada | 19.06.2022 | Orlando City | - | Houston Dynamo | 2:1 | ||||
| 5. Jornada | 26.06.2022 | Houston Dynamo | - | Chicago Fire | 2:0 | ||||
| 6. Jornada | 04.07.2022 | Houston Dynamo | - | Charlotte FC | 1:2 | ||||
| 6. Jornada | 18.07.2022 | San Jose Earthquakes | - | Houston Dynamo | 1:2 | ||||
| 6. Jornada | 31.07.2022 | Philadelphia Union | - | Houston Dynamo | 6:0 |
Canadá