| 1. Jornada | 17.08.2018 | FC Twente | - | Sparta Rotterdam | 2:1 |  |
|||
| 2. Jornada | 24.08.2018 | Helmond Sport | - | FC Twente | 2:2 | ||||
| 3. Jornada | 31.08.2018 | FC Twente | - | Roda JC Kerkrade | 3:1 | |
|||
| 4. Jornada | 08.09.2018 | FC Twente | - | TOP Oss | 1:2 | ||||
| 5. Jornada | 14.09.2018 | FC Dordrecht | - | FC Twente | 0:2 | ||||
| 8. Jornada | 05.10.2018 | FC Eindhoven | - | FC Twente | 1:1 | ||||
| 9. Jornada | 14.10.2018 | FC Twente | - | MVV | 0:1 | ||||
| 11. Jornada | 26.10.2018 | FC Twente | - | Almere City FC | 1:0 | ||||
| 22. Jornada | 26.01.2019 | Almere City FC | - | FC Twente | 1:3 | ||||
| 35. Jornada | 29.04.2019 | Jong Ajax | - | FC Twente | 2:5 | |
Camerún