| 3. Jornada | 23.06.2021 | Orlando City | - | San Jose Earthquakes | 5:0 | ||||
| 3. Jornada | 26.06.2021 | Inter Miami CF | - | Orlando City | 1:2 | ||||
| 4. Jornada | 04.07.2021 | Orlando City | - | New York RB | 1:2 | ||||
| 4. Jornada | 08.07.2021 | Chicago Fire | - | Orlando City | 3:1 | ||||
| 4. Jornada | 18.07.2021 | Toronto FC | - | Orlando City | 1:1 | ||||
| 4. Jornada | 23.07.2021 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| 4. Jornada | 26.07.2021 | New York City FC | - | Orlando City | 5:0 | ||||
| 4. Jornada | 31.07.2021 | Orlando City | - | Atlanta United FC | 3:2 | ||||
| 5. Jornada | 05.08.2021 | Orlando City | - | Inter Miami CF | 1:1 |  |
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| 5. Jornada | 08.08.2021 | FC Cincinnati | - | Orlando City | 1:1 | ||||
| 6. Jornada | 11.09.2021 | Atlanta United FC | - | Orlando City | 3:0 | ||||
| 7. Jornada | 17.10.2021 | FC Cincinnati | - | Orlando City | 0:1 | ||||
| 7. Jornada | 21.10.2021 | Orlando City | - | CF Montréal | 1:1 | |
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| 8. Jornada | 07.11.2021 | CF Montréal | - | Orlando City | 0:2 |
España