| 1. Jornada | 17.02.2022 | Cobreloa | - | San Luis | 2:1 |  |
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| 2. Jornada | 23.02.2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 3. Jornada | 03.03.2022 | Barnechea | - | San Luis | 3:1 | |
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| 5. Jornada | 17.03.2022 | San Luis | - | Santiago Morning | 1:2 | ||||
| 6. Jornada | 23.03.2022 | Rangers | - | San Luis | 2:3 | |
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| 7. Jornada | 03.04.2022 | San Luis | - | Deportes Copiapó | 0:0 | ||||
| 8. Jornada | 12.04.2022 | Unión San Felipe | - | San Luis | 2:0 | ||||
| 9. Jornada | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | |
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| 10. Jornada | 22.04.2022 | Puerto Montt | - | San Luis | 1:1 |  |
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| 12. Jornada | 30.04.2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 13. Jornada | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 14. Jornada | 13.05.2022 | San Luis | - | Fernández Vial | 0:0 | ||||
| 16. Jornada | 24.05.2022 | Recoleta | - | San Luis | 2:3 | |
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| 17. Jornada | 01.06.2022 | San Luis | - | Universidad de Concepción | 0:2 | |
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| 18. Jornada | 05.07.2022 | San Luis | - | Cobreloa | 0:0 | ||||
| 20. Jornada | 16.07.2022 | San Luis | - | Barnechea | 1:0 | ||||
| 21. Jornada | 26.07.2022 | Santiago Wanderers | - | San Luis | 1:2 | ||||
| 22. Jornada | 01.08.2022 | Santiago Morning | - | San Luis | 1:0 | ||||
| 23. Jornada | 09.08.2022 | San Luis | - | Rangers | 0:0 | |
Argentina