| 1. Jornada | 18.07.2010 | Club Nacional | - | Cerro Porteño | 0:0 | ||||
| 2. Jornada | 25.07.2010 | Club Nacional | - | Club Olimpia | 0:2 | ||||
| 3. Jornada | 01.08.2010 | Sol de América | - | Club Nacional | 1:0 | ||||
| 4. Jornada | 07.08.2010 | Club Nacional | - | Sportivo Trinidense | 4:1 | ||||
| 5. Jornada | 14.08.2010 | Sportivo Luqueño | - | Club Nacional | 0:1 | ||||
| 6. Jornada | 22.08.2010 | Guaraní | - | Club Nacional | 0:0 |  |
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| 7. Jornada | 29.08.2010 | Sport Colombia | - | Club Nacional | 1:2 | |
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| 8. Jornada | 04.09.2010 | Club Nacional | - | Club Rubio Ñu | 0:0 | ||||
| 9. Jornada | 12.09.2010 | Libertad | - | Club Nacional | 1:0 |  |
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| 12. Jornada | 03.10.2010 | Cerro Porteño | - | Club Nacional | 1:1 | |
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| 16. Jornada | 24.10.2010 | Club Nacional | - | Sportivo Luqueño | 2:0 | ||||
| 17. Jornada | 30.10.2010 | Club Nacional | - | Guaraní | 0:1 | ||||
| 18. Jornada | 06.11.2010 | Club Nacional | - | Sport Colombia | 4:3 |  |
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| 19. Jornada | 12.11.2010 | Club Rubio Ñu | - | Club Nacional | 1:1 | |
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| 20. Jornada | 21.11.2010 | Club Nacional | - | Libertad | 1:0 | |
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| 21. Jornada | 27.11.2010 | 3 de Febrero | - | Club Nacional | 1:2 | |
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| 22. Jornada | 03.12.2010 | Tacuary | - | Club Nacional | 1:2 | |
Paraguay