| 5. Jornada | 12.02.2022 | CF Monterrey [Sub 18] | - | FC Juárez [Sub 18] | 2:1 | ||||
| 6. Jornada | 18.02.2022 | Puebla FC [Sub 18] | - | CF Monterrey [Sub 18] | 1:1 | ||||
| 8. Jornada | 01.03.2022 | Club León [Sub 18] | - | CF Monterrey [Sub 18] | 2:0 | ||||
| 9. Jornada | 05.03.2022 | CF Monterrey [Sub 18] | - | CF América [Sub 18] | 3:5 |  |
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| 10. Jornada | 11.03.2022 | CF Monterrey [Sub 18] | - | Mazatlán FC [Sub 18] | 2:2 | |
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| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 18] | - | CF Monterrey [Sub 18] | 0:4 | |
 |
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| 13. Jornada | 26.03.2022 | CF Monterrey [Sub 18] | - | Santos Laguna [Sub 18] | 1:2 | ||||
| 12. Jornada | 02.04.2022 | Deportivo Guadalajara [Sub 18] | - | CF Monterrey [Sub 18] | 4:0 | ||||
| 15. Jornada | 20.04.2022 | CF Monterrey [Sub 18] | - | Atlas Guadalajara [Sub 18] | 0:2 | ||||
| 16. Jornada | 23.04.2022 | CF Pachuca [Sub 18] | - | CF Monterrey [Sub 18] | 2:1 | ||||
| 17. Jornada | 30.04.2022 | CF Monterrey [Sub 18] | - | Club Tijuana [Sub 18] | 1:1 |
México