| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 18] | - | Atlético San Luis [Sub 18] | 1:1 | ||||
| 14. Jornada | 21.09.2021 | FC Juárez [Sub 18] | - | Atlético San Luis [Sub 18] | 0:3 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca [Sub 18] | - | Atlético San Luis [Sub 18] | 1:1 |  |
|||
| 11. Jornada | 29.09.2021 | Atlético San Luis [Sub 18] | - | UANL Tigres [Sub 18] | 0:5 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 18] | - | Atlético San Luis [Sub 18] | 4:3 | ||||
| 13. Jornada | 16.10.2021 | Atlético San Luis [Sub 18] | - | CF América [Sub 18] | 1:1 |
México