| 1. Jornada | 17.07.2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 2. Jornada | 20.07.2022 | Libertad | - | Club Olimpia | 4:2 |  |
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| 3. Jornada | 24.07.2022 | Club Olimpia | - | Guaireña FC | 2:1 |  |
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| 4. Jornada | 31.07.2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 7. Jornada | 20.08.2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 12. Jornada | 20.09.2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 14. Jornada | 02.10.2022 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 15. Jornada | 06.10.2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Jornada | 09.10.2022 | Sportivo Ameliano | - | Club Olimpia | 0:2 | ||||
| 13. Jornada | 13.10.2022 | Club Olimpia | - | Libertad | 1:0 | |
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| 17. Jornada | 16.10.2022 | Cerro Porteño | - | Club Olimpia | 1:2 | ||||
| 18. Jornada | 23.10.2022 | Club Olimpia | - | General Caballero DJLM | 2:1 |  |
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| 21. Jornada | 08.11.2022 | Sol de América | - | Club Olimpia | 0:2 | ||||
| 22. Jornada | 12.11.2022 | Club Olimpia | - | Club Nacional | 1:1 |
Argentina