| 2. Jornada | 31.07.2021 | Cercle Brugge | - | Oud-Heverlee Leuven | 1:1 |  |
|||
| 3. Jornada | 06.08.2021 | Club Brugge KV | - | Cercle Brugge | 1:1 | |
|||
| 4. Jornada | 15.08.2021 | Cercle Brugge | - | RSC Anderlecht | 1:2 |  |
|||
| 5. Jornada | 21.08.2021 | RFC Seraing | - | Cercle Brugge | 2:1 | ||||
| 6. Jornada | 28.08.2021 | Cercle Brugge | - | Sint-Truidense VV | 0:1 | ||||
| 7. Jornada | 11.09.2021 | SV Zulte Waregem | - | Cercle Brugge | 2:4 | ||||
| 8. Jornada | 17.09.2021 | Cercle Brugge | - | KAS Eupen | 1:2 | ||||
| 10. Jornada | 02.10.2021 | Cercle Brugge | - | Union Saint-Gilloise | 0:3 | |
|||
| 11. Jornada | 16.10.2021 | KV Oostende | - | Cercle Brugge | 2:1 | ||||
| 15. Jornada | 20.11.2021 | Cercle Brugge | - | Sporting Charleroi | 1:2 | ||||
| 16. Jornada | 27.11.2021 | Cercle Brugge | - | KV Mechelen | 3:1 |
España