| 2. Jornada | 26.07.2021 | Atlético Junior | - | Envigado FC | 1:0 |  |
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| 3. Jornada | 01.08.2021 | Independiente Medellín | - | Atlético Junior | 0:0 | ||||
| 4. Jornada | 09.08.2021 | Atlético Junior | - | Deportes Tolima | 0:0 | ||||
| 5. Jornada | 15.08.2021 | Jaguares de Córdoba | - | Atlético Junior | 1:1 | ||||
| 6. Jornada | 22.08.2021 | Atlético Junior | - | Once Caldas | 4:2 | ||||
| 8. Jornada | 23.09.2021 | Atlético Junior | - | Atlético Huila | 3:0 | ||||
| 11. Jornada | 25.09.2021 | Águilas Doradas | - | Atlético Junior | 1:2 | |
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| 12. Jornada | 02.10.2021 | Atlético Junior | - | Patriotas FC | 1:0 | ||||
| 13. Jornada | 12.10.2021 | Atlético Bucaramanga | - | Atlético Junior | 1:1 | |
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| 14. Jornada | 18.10.2021 | Atlético Junior | - | Jaguares de Córdoba | 2:1 | ||||
| 15. Jornada | 24.10.2021 | Millonarios | - | Atlético Junior | 4:1 | |
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| 20. Jornada | 21.11.2021 | Alianza Petrolera | - | Atlético Junior | 1:1 |
Colombia