| 1. Jornada | 31.07.2022 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 2. Jornada | 06.08.2022 | River Plate | - | Plaza Colonia | 2:0 | ||||
| 3. Jornada | 12.08.2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Jornada | 20.08.2022 | Fénix | - | River Plate | 1:2 | ||||
| 5. Jornada | 29.08.2022 | Cerro Largo | - | River Plate | 0:5 | ||||
| 4. Jornada | 05.09.2022 | Cerrito | - | River Plate | 1:5 | ||||
| 7. Jornada | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 8. Jornada | 14.09.2022 | Albion | - | River Plate | 0:2 | ||||
| 9. Jornada | 17.09.2022 | River Plate | - | Nacional | 1:1 | ||||
| 10. Jornada | 24.09.2022 | Danubio | - | River Plate | 3:0 | ||||
| 11. Jornada | 02.10.2022 | River Plate | - | Deportivo Maldonado | 0:0 | ||||
| 12. Jornada | 08.10.2022 | Rentistas | - | River Plate | 0:5 |  |
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| 13. Jornada | 13.10.2022 | River Plate | - | Liverpool | 0:1 | ||||
| 14. Jornada | 16.10.2022 | Peñarol | - | River Plate | 1:1 | ||||
| 15. Jornada | 21.10.2022 | River Plate | - | Montevideo City Torque | 2:1 |
Paraguay