| Grupo B | 10.06.2022 | River Plate | - | Cerrito | 3:0 |  |
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| Grupo B | 18.06.2022 | Nacional | - | River Plate | 3:0 | ||||
| Grupo B | 26.06.2022 | River Plate | - | Boston River | 0:1 | ||||
| Grupo B | 10.07.2022 | Danubio | - | River Plate | 1:3 | ||||
| Grupo B | 16.07.2022 | Plaza Colonia | - | River Plate | 0:0 | ||||
| Grupo B | 21.07.2022 | River Plate | - | Defensor Sporting | 1:1 | ||||
| Grupo B | 25.07.2022 | Cerro Largo | - | River Plate | 0:0 |
Paraguay