| 4. Jornada | 25.06.2021 | Uruguay Montevideo | - | Albion | 2:2 | ||||
| 5. Jornada | 02.07.2021 | Uruguay Montevideo | - | Rampla Juniors | 2:0 | ||||
| 6. Jornada | 08.07.2021 | Danubio | - | Uruguay Montevideo | 1:0 |  |
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| 7. Jornada | 14.07.2021 | Uruguay Montevideo | - | Rocha | 2:1 | ||||
| 8. Jornada | 21.07.2021 | CA Cerro | - | Uruguay Montevideo | 0:1 | ||||
| 9. Jornada | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | |
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| 10. Jornada | 05.08.2021 | Central Español | - | Uruguay Montevideo | 1:3 | ||||
| 11. Jornada | 12.08.2021 | Uruguay Montevideo | - | Atenas | 0:0 | ||||
| 12. Jornada | 16.09.2021 | Uruguay Montevideo | - | Racing | 1:2 | ||||
| 13. Jornada | 21.09.2021 | Villa Teresa | - | Uruguay Montevideo | 0:1 | ||||
| 14. Jornada | 28.09.2021 | Uruguay Montevideo | - | Juventud de Las Piedras | 1:0 | ||||
| 15. Jornada | 04.10.2021 | Albion | - | Uruguay Montevideo | 1:0 | ||||
| 16. Jornada | 13.10.2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | |
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| 18. Jornada | 27.10.2021 | Rocha | - | Uruguay Montevideo | 1:2 | ||||
| 19. Jornada | 03.11.2021 | Uruguay Montevideo | - | CA Cerro | 1:2 |  |
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| 21. Jornada | 18.11.2021 | Uruguay Montevideo | - | Central Español | 0:3 | ||||
| 22. Jornada | 23.11.2021 | Atenas | - | Uruguay Montevideo | 0:0 | |
Uruguay